Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury

C Van Der Poel; LE Gosselin; JD Schertzer; JG Ryall; K Swiderski; M Wondemaghen; GS Lynch

Journal article

Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury

C Van Der Poel, LE Gosselin, JD Schertzer, JG Ryall, K Swiderski, M Wondemaghen, GS Lynch

Journal of Inflammation | Published : 2011

DOI: 10.1186/1476-9255-8-41

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Abstract

Background: Some of the most serious consequences of normal ageing relate to its effects on skeletal muscle, particularly significant wasting and associated weakness, termed "sarcopenia". The underlying mechanisms of sarcopenia have yet to be elucidated completely but an altered muscle inflammatory response after injury is a likely contributing factor. In this study we investigated age-related changes in the expression of numerous inflammatory markers linked to successful muscle regeneration. Methods. Right extensor digitorum longus (EDL) muscles from young (3 month), adult (12 month) and old (24 month) male F344 rats were injected with bupivacaine hydrochloride to cause complete muscle fibr..

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University of Melbourne Researchers

Kristy Swiderski Author

Gordon Lynch Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

Supported by research grant funding from the Australian Research Council Discovery-Project funding scheme (DP0665071), the National Health and Medical Research Council of Australia (350439) and the Rebecca L. Cooper Medical Research Foundation.